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DTSTAMP:20261112T155535Z
LAST-MODIFIED:20261104T053034Z
DTSTART:20261113T210000Z
DTEND:20261113T230000Z
SUMMARY:PhD Dissertation Defense: Danielle Klinger
DESCRIPTION:Title: Non-Destructive Contractility Measurements on Developing
  Cardioids Abstract: The force generated by the heart depends in part on h
 ow much the cardiac muscle is stretched\, and diseases that disrupt this m
 echanical function\, are a major cause of heart failure. Cardioids are 3D 
 engineered heart tissues\, derived from human stem cells\, that beat spont
 aneously and reproduce features of the developing heart\, making them prom
 ising models for studying disease and testing drugs. However\, measuring t
 heir mechanical function without disrupting the tissue remains challenging
 . In this work\, I developed a non-destructive compression assay to measur
 e contractile force and passive stiffness in intact cardioids. First\, I a
 pplied it to track individual cardioids throughout maturation and showed t
 hat they become smaller\, generate more force\, and perform more mechanica
 l work with each beat as they mature\, similar to the developing human hea
 rt. Second\, I demonstrated that cardioids exhibit a…\n\nhttps://localz.
 events/e/phd-dissertation-defense-danielle-klinger-151463
LOCATION:Clark Center\, 318 Campus Drive\, Stanford\, CA 94305\, Palo Alto
GEO:37.431462;-122.174561
URL:https://localz.events/e/phd-dissertation-defense-danielle-klinger-15146
 3
STATUS:CONFIRMED
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